
Paulraj Kanmani and Jong-Whan Rhim at Mokpo National University published a study in 2014 demonstrating a high potential for a carrageenan and GSE composite film being used for active food packaging or for antimicrobial properties as the blend showed strong antibacterial activity against food borne pathogens. GSE is found in natural disinfectants and as a natural preservative in products to prevent mold and bacteria contaminants. The Journal of Physiology and Pharmacology published a study in 2004 concluding that GSE has protective activity against pancreatitis. Adeneye at Lagos State University College of Medicine, Nigeria, conducted a study on rats that validated the extract's use for weight loss and blood sugar, as well as lowering the risk of cardiovascular disease. South-West Nigeria has traditionally used grapefruit seed extract for managing weight and diabetes. Other benefits of the extract is include fighting the common cold, flu, and yeast infections. Today, many individuals use the extract to treat many conditions, including: Hospitals began using the compound as an antiseptic, and it has been used in pools as a natural alternative to chlorine. It was traditionally used in agriculture to prevent mold from growing on foodstuff. He found that the extract deactivated fungi (including yeast), parasites, and viruses.

Jakob Harich discovered grapefruit seed extract from processing the seeds and pulp into a bitter-tasting, highly acidic liquid.

It is highly regarded not just for its antimicrobial effects, but for its safe usage. In 1972, Dr. Grapefruit Seed Extract (GSE) is one of the most potent antifungal, antibacterial, and antimicrobial natural products.
